B symptoms
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The B symptoms (a.k.a. inflammatory symptoms) are a triad of systemic symptoms associated with more advanced disease and a poorer outcome in lymphoma 1,2:
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weight loss
,- >10% unintentional decrease in body weight in the 6 months preceding the diagnosis
- fever: >38°C
- night sweats
*some references state >5% 1
B symptoms are a poor prognostic factor in lymphoma (both Hodgkin and non-Hodgkin lymphomas). For this reason, if there are B symptoms, then the tumour is upstaged under the Lugano classification system. The presence of B symptoms correlates well with an elevated level of inflammatory cytokines in body fluids 1.
-<p>The <strong>B symptoms</strong> are <a title="Weight loss" href="/articles/weight-loss">weight loss</a>, <a title="Fever" href="/articles/pyrexia">fever</a> and <a title="Night sweats" href="/articles/night-sweats">night sweats</a>.</p><p> </p>- +<p>The <strong>B symptoms</strong> (a.k.a. <strong>inflammatory symptoms</strong>) are a triad of systemic symptoms associated with more advanced disease and a poorer outcome in <a href="/articles/lymphoma">lymphoma</a> <sup>1,2</sup>:</p><ul>
- +<li>
- +<a href="/articles/weight-loss">weight loss</a><ul><li>>10% unintentional decrease in body weight in the 6 months preceding the diagnosis</li></ul>
- +</li>
- +<li>
- +<a href="/articles/pyrexia">fever</a>: >38°C</li>
- +<li><a href="/articles/night-sweats">night sweats</a></li>
- +</ul><p>*some references state >5% <sup>1</sup></p><p>B symptoms are a poor prognostic factor in lymphoma (both <a href="/articles/hodgkin-lymphoma">Hodgkin</a> and <a href="/articles/non-hodgkin-lymphoma">non-Hodgkin</a> lymphomas). For this reason, if there are B symptoms, then the tumour is upstaged under the <a title="Lugano classification" href="/articles/lugano-classification-1">Lugano classification system</a>. The presence of B symptoms correlates well with an elevated level of inflammatory cytokines in body fluids <sup>1</sup>.</p>
References changed:
- 1. Sharma R, Cunningham D, Smith P, Robertson G, Dent O, Clarke SJ. Inflammatory (B) symptoms are independent predictors of myelosuppression from chemotherapy in Non-Hodgkin Lymphoma (NHL) patients--analysis of data from a British National Lymphoma Investigation phase III trial comparing CHOP to PMitCEBO. (2009) BMC cancer. 9: 153. <a href="https://doi.org/10.1186/1471-2407-9-153">doi:10.1186/1471-2407-9-153</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19450285">Pubmed</a> <span class="ref_v4"></span>
- 2. Shanbhag S, Ambinder RF. Hodgkin lymphoma: A review and update on recent progress. (2018) CA: a cancer journal for clinicians. 68 (2): 116-132. <a href="https://doi.org/10.3322/caac.21438">doi:10.3322/caac.21438</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29194581">Pubmed</a> <span class="ref_v4"></span>
Systems changed:
- Haematology
- Oncology
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B symptoms
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