Citation, DOI, disclosures and article data
Citation:
Knipe H, Al Khateeb A, Vadera S, et al. Bone marrow reconversion. Reference article, Radiopaedia.org (Accessed on 30 Mar 2025) https://doi.org/10.53347/rID-147089
Disclosures:
At the time the article was created Henry Knipe had the following disclosures:
- Radiopaedia Events Pty Ltd, Speaker fees (past)
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Micro-X Ltd, Shareholder (past)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Bone marrow reconversion, also known as diffuse hematopoietic marrow hyperplasia 5,6, generates a red bone marrow pattern that is in reverse to the normal red-to-yellow distribution.
Bone marrow reconversion occurs when there is increased hematopoietic demand, which may be 1,2,5,6:
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physiological
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iatrogenic
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pathological
MRI
Signal intensity will be that of normal red marrow being low T1 signal but still higher than skeletal muscle 1,3. In the appendicular skeleton, it tends to be symmetrical and homogeneous, whereas in the axial skeletal it can be heterogeneous/multifocal 1. Marrow reconversion occurs in the reverse order of normal red to yellow marrow conversion 4.
Bone marrow reconversion happens in the following EXCEPT...
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1. Saifuddin A, Tyler P, Rajakulasingam R. Imaging of Bone Marrow Pitfalls with Emphasis on MRI. BJR. 2022;:20220063. doi:10.1259/bjr.20220063 - Pubmed
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2. Małkiewicz A & Dziedzic M. Bone Marrow Reconversion - Imaging of Physiological Changes in Bone Marrow. Pol J Radiol. 2012;77(4):45-50. doi:10.12659/pjr.883628 - Pubmed
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3. Chiarilli M, Delli Pizzi A, Mastrodicasa D et al. Bone Marrow Magnetic Resonance Imaging: Physiologic and Pathologic Findings That Radiologist Should Know. Radiol Med. 2020;126(2):264-76. doi:10.1007/s11547-020-01239-2 - Pubmed
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4. Musculoskeletal Diseases 2021-2024. IDKD Springer Series. 2021. doi:10.1007/978-3-030-71281-5
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5. Vande Berg B, Lecouvet F, Galant C, Maldague B, Malghem J. Normal Variants and Frequent Marrow Alterations That Simulate Bone Marrow Lesions at MR Imaging. Radiol Clin North Am. 2005;43(4):761-70. doi:10.1016/j.rcl.2005.01.007 - Pubmed
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6. Hwang S & Panicek D. Magnetic Resonance Imaging of Bone Marrow in Oncology, Part 1. Skeletal Radiol. 2007;36(10):913-20. doi:10.1007/s00256-007-0309-3 - Pubmed
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