Bronchocentric granulomatosis
Updates to Article Attributes
Bronchocentric granulomatosis (BG) is a rare chronic condition involving the lung and is sometimes included in the spectrum of eosinophilic lung disease 7.
Epidemiology
It can affect a wide age spectrum of patients but is thought to peak between the 4th to 7th decades 6.
Pathology
Its underlying cause is is often unclear.
It is characterised by a necrotizing granulomatous inflammation of bronchial and bronchiolar epithelium with chronic inflammatory changes in the surrounding lung parenchyma.
The current pathogenetic mechanism is considered to be an immunologic reaction against endobronchial antigens 3.
Associations
Approximately one-third to helfhalf of affected patients have tissue eosinophilia and tend to have a combination of asthma, peripheral eosinophilia, fungal hyphae at biopsy, and positive sputum cultures for Aspergillus organisms.
Other rare reported associations include
- rheumatoid arthritis - see - pulmonary manifestations of rheumatoid arthritis 8
Radiographic features
CT - HRCT
CT features of bronchocentric granulomatosis are non specific-specific and can include a a focal mass or lobar consolidation with atelectasis.
Treatment and prognosis
It is usually treated with short-term corticosteroids corticosteroids and tends tends to have a favourable favourable overall prognosis prognosis 4. Some case may resolve spontaneously 6.
Etymology
It is thought to have been initially described by Liebow et al. in 1973 6.
-<p><strong>Bronchocentric granulomatosis (BG)</strong> is a rare chronic condition involving the lung and is sometimes included in the spectrum of <a title="Eosinophilic lung disease" href="/articles/eosinophilic-lung-disease-1">eosinophilic lung disease</a> <sup>7</sup>.</p>-<h4>Epidemiology</h4>-<p>It can affect a wide age spectrum of patients but is thought to peak between the 4<sup>th</sup> to 7<sup>th</sup> decades <sup>6</sup>.</p>-<h4>Pathology</h4>-<p>Its underlying cause is often unclear. </p>-<p>It is characterised by a necrotizing granulomatous inflammation of bronchial and bronchiolar epithelium with chronic inflammatory changes in the surrounding lung parenchyma. </p>-<p>The current pathogenetic mechanism is considered to be an immunologic reaction against endobronchial antigens <sup>3</sup>.</p>-<h5>Associations</h5>-<p>Approximately one-third to helf of affected patients have tissue eosinophilia and tend to have a combination of asthma, peripheral eosinophilia, fungal hyphae at biopsy, and positive sputum cultures for <em><a title="Aspergillus species" href="/articles/aspergillus">Aspergillus </a></em>organisms.</p>-<p>Other rare reported associations include</p>-<ul><li>rheumatoid arthritis - see - <a title="Pulmonary manifestations of rheumatoid arthritis" href="/articles/respiratory-manifestations-of-rheumatoid-arthritis">pulmonary manifestations of rheumatoid arthritis</a> <sup>8</sup>-</li></ul><h4>Radiographic features</h4>-<h5>CT - HRCT</h5>-<p>CT features of bronchocentric granulomatosis are non specific and can include a focal mass or lobar consolidation with atelectasis.</p>-<h4>Treatment and prognosis</h4>-<p>It is usually treated with short-term corticosteroids and tends to have a favourable overall prognosis <sup>4</sup>. Some case may resolve spontaneously <sup>6</sup>.</p>-<h4>Etymology</h4>-<p>It is thought to have been initially described by <strong>Liebow </strong>et al in 1973 <sup>6</sup>.</p>- +<p><strong>Bronchocentric granulomatosis (BG)</strong> is a rare chronic condition involving the lung and is sometimes included in the spectrum of <a href="/articles/eosinophilic-lung-disease-1">eosinophilic lung disease</a> <sup>7</sup>.</p><h4>Epidemiology</h4><p>It can affect a wide age spectrum of patients but is thought to peak between the 4<sup>th</sup> to 7<sup>th</sup> decades <sup>6</sup>.</p><h4>Pathology</h4><p>Its underlying cause is often unclear.</p><p>It is characterised by a necrotizing granulomatous inflammation of bronchial and bronchiolar epithelium with chronic inflammatory changes in the surrounding lung parenchyma.</p><p>The current pathogenetic mechanism is considered to be an immunologic reaction against endobronchial antigens <sup>3</sup>.</p><h5>Associations</h5><p>Approximately one-third to half of affected patients have tissue eosinophilia and tend to have a combination of asthma, peripheral eosinophilia, fungal hyphae at biopsy, and positive sputum cultures for <em><a href="/articles/aspergillus">Aspergillus </a></em>organisms.</p><p>Other rare reported associations include</p><ul><li>rheumatoid arthritis - see - <a href="/articles/rheumatoid-arthritis-pulmonary-manifestations">pulmonary manifestations of rheumatoid arthritis</a> <sup>8</sup>
- +</li></ul><h4>Radiographic features</h4><h5>CT - HRCT</h5><p>CT features of bronchocentric granulomatosis are non-specific and can include a focal mass or lobar consolidation with atelectasis.</p><h4>Treatment and prognosis</h4><p>It is usually treated with short-term corticosteroids and tends to have a favourable overall prognosis <sup>4</sup>. Some case may resolve spontaneously <sup>6</sup>.</p><h4>Etymology</h4><p>It is thought to have been initially described by <strong>Liebow </strong>et al. in 1973 <sup>6</sup>.</p>