Cogan syndrome
Updates to Article Attributes
Cogan syndrome is a rarevasculitis of children and young adults which primarily characterized by 1,4,6:
- inflammatory eye disease (ocular keratitis, uveitis, scleritis, optic neuritis) 6
- audiovestibular symptoms (similar to Meniere disease) 6
However, it can potentially affect a multitude of other organs (classically aortitis) 4.
Pathology
Aetiology
The exact aetiology is not well known although an autoimmune aetiology has been postulated.
Disease progression
The onset of the disease is usually rapid with ocular findings preceding tinnitus and vertigo. If untreated the majority of patients will become deaf and 5% will be blind. Aortitis and aortic insufficiency develop in 10-15% of patients. Prognosis is good in patients without patients without symptoms of aortitis and early steroid treatment may prevent deafnesssdeafness 6.
History and etymology
It was initially described by David Glendenning Cogan, American ophthalmologist (1908-1993) in 1945 5.
-<p><strong>Cogan syndrome</strong> is a rare <a href="/articles/vasculitis">vasculitis</a> of children and young adults which primarily characterized by <sup>1,4,6</sup>:</p><ul>-<li>inflammatory eye disease (<a title="ocular keratitis" href="/articles/ocular-keratitis">ocular keratitis</a>, <a title="uveitis" href="/articles/uveitis">uveitis</a>, <a title="Scleritis" href="/articles/scleritis">scleritis</a>, <a href="/articles/optic-neuritis">optic neuritis</a>) <sup>6</sup>- +<p><strong>Cogan syndrome</strong> is a rare <a href="/articles/vasculitis">vasculitis</a> of children and young adults which primarily characterized by <sup>1,4,6</sup>:</p><ul>
- +<li>inflammatory eye disease (<a href="/articles/ocular-keratitis">ocular keratitis</a>, <a href="/articles/uveitis">uveitis</a>, <a href="/articles/scleritis">scleritis</a>, <a href="/articles/optic-neuritis">optic neuritis</a>) <sup>6</sup>
-</ul><p>However, it can potentially affect a multitude of other organs (classically <a href="/articles/aortitis">aortitis</a>) <sup>4</sup>.</p><h4>Pathology</h4><h5>Aetiology</h5><p>The exact aetiology is not well known although an autoimmune aetiology has been postulated. </p><h5>Disease progression</h5><p>The onset of the disease is usually rapid with ocular findings preceding tinnitus and vertigo. If untreated the majority of patients will become deaf and 5% will be blind. <a href="/articles/aortitis">Aortitis</a> and aortic insufficiency develop in 10-15% of patients. Prognosis is good in patients without symptoms of aortitis and early steroid treatment may prevent deafnesss <sup>6</sup>.</p><h4>History and etymology</h4><p>It was initially described by <strong>David Glendenning Cogan,</strong> American ophthalmologist (1908-1993) in 1945 <sup>5</sup>.</p>- +</ul><p>However, it can potentially affect a multitude of other organs (classically <a href="/articles/aortitis">aortitis</a>) <sup>4</sup>.</p><h4>Pathology</h4><h5>Aetiology</h5><p>The exact aetiology is not well known although an autoimmune aetiology has been postulated. </p><h5>Disease progression</h5><p>The onset of the disease is usually rapid with ocular findings preceding tinnitus and vertigo. If untreated the majority of patients will become deaf and 5% will be blind. <a href="/articles/aortitis">Aortitis</a> and aortic insufficiency develop in 10-15% of patients. Prognosis is good in patients without symptoms of aortitis and early steroid treatment may prevent deafness <sup>6</sup>.</p><h4>History and etymology</h4><p>It was initially described by <strong>David Glendenning Cogan,</strong> American ophthalmologist (1908-1993) in 1945 <sup>5</sup>.</p>