Necrosis
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Necrosis (term)
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Necrosis (plural: necroses) is defined as unregulated cell death. This is in contrast to apoptosis, which is a form of regulated, or programmed, cell death 1.
Necrosis is the most common type of cell death observed in injury/disease. It occurs when cellular damage is so severe that lysosomal enzymes enter the cytoplasm, causing autodigestion of the cell 1.
TypesThe main types of Necrosisnecrosis are:
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Coagulative - tissuecoagulative: tissue architecture is preserved -
Liquefactive - lossliquefactive: loss of tissue architecture, formation of liquid/pus -
Caseous - mostcaseous: most common with tuberculosisinfection; friable, structureless cell debris -
Fatfat necrosis- refers: refers to local areas of fat destruction, commonly encountered in pancreatitis 1.
-<p><strong>Necrosis</strong> is defined as unregulated cell death. This is in contrast to apoptosis, which is a form of regulated, or programmed, cell death <sup>1</sup>. </p><p>Necrosis is the most common type of cell death observed in injury/disease. It occurs when cellular damage is so severe that lysosomal enzymes enter the cytoplasm, causing autodigestion of the cell <sup>1</sup>. </p><p>Types of Necrosis:</p><ul>-<li>Coagulative - tissue architecture is preserved </li>-<li>Liquefactive - loss of tissue architecture, formation of liquid/pus</li>-<li>Caseous - most common with tuberculosis infection; friable, structureless cell debris</li>-<li>Fat necrosis - refers to local areas of fat destruction, commonly encountered in pancreatitis <sup>1</sup>.</li>- +<p><strong>Necrosis</strong> (plural: necroses) is defined as unregulated cell death. This is in contrast to <a title="Apoptosis" href="/articles/apoptosis">apoptosis</a>, which is a form of regulated, or programmed, cell death <sup>1</sup>. </p><p>Necrosis is the most common type of cell death observed in injury/disease. It occurs when cellular damage is so severe that lysosomal enzymes enter the cytoplasm, causing autodigestion of the cell <sup>1</sup>. </p><p>The main types of necrosis are:</p><ul>
- +<li>coagulative: tissue architecture is preserved </li>
- +<li>liquefactive: loss of tissue architecture, formation of liquid/pus</li>
- +<li>caseous: most common with <a title="Tuberculosis" href="/articles/tuberculosis">tuberculosis</a>; friable, structureless cell debris</li>
- +<li>fat necrosis: refers to local areas of fat destruction, commonly encountered in <a title="Pancreatitis" href="/articles/pancreatitis">pancreatitis</a> <sup>1</sup>
- +</li>
References changed:
- 1. Vinay Kumar, Abul K. Abbas, Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. (2014) <a href="https://books.google.co.uk/books?vid=ISBN9780323266161">ISBN: 9780323266161</a><span class="ref_v4"></span>
- 1. Robbins S, Cotran R, Kumar V, Abbas A, Aster J. Pathologic basis of disease. Philadelphia, PA: Saunders Elsevier; 2015.
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