Primary lateral sclerosis

Last revised by Francis Deng ◉ on 17 Apr 2022

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Deng F, Bell D, Primary lateral sclerosis. Reference article, Radiopaedia.org (Accessed on 25 Mar 2025) https://doi.org/10.53347/rID-76761

DOI:

https://doi.org/10.53347/rID-76761

Permalink:

https://radiopaedia.org/articles/76761

rID:

76761

Article created:

28 Apr 2020, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

17 Apr 2022, Francis Deng ◉

Disclosures:

At the time the article was last revised Francis Deng had no financial relationships to ineligible companies to disclose.

View Francis Deng's current disclosures

Revisions:

3 times, by 3 contributors - see full revision history and disclosures

Systems:

Central Nervous System

Synonyms:

Primary lateral sclerosis (PLS)

Primary lateral sclerosis (PLS) is a form of motor neurone disease (MND).

Clinical presentation

Diagnosis

The diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics.

Pathology

It is characterised by a slowly progressive upper motor neurone syndrome.

Radiographic features

MRI

MRI shows prominent precentral gyrus atrophy and T2/FLAIR hyperintensity in the corticospinal tracts in the brain and spinal cord ³.

Differential diagnosis

upper motor neurone-predominant forms of amyotrophic lateral sclerosis: remains a significant challenge in the early symptomatic phase ¹

References

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Primary lateral sclerosis