Radiation-induced cerebral vasculopathy
Updates to Article Attributes
Radiation-induced vasculopathy encompasses a complex and broad range of effects on the intra and extracranial vessels resulting from injury from radiation exposure.
Clinical presentation
Clinical symptoms are broad and depend on the underlying vasculopathy. Radiation-induced telangiectasia and microbleeds may be asymptomatic. However, patients may present with focal neurological deficits resulting from both haemorrhagic and ischaemic stroke, lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and radiation-induced necrosis.
Pathology
Biopsy and pathological analysis of radiation-induced telangiectasias has demonstrated deposition of perivascular hemosiderin and hemorrhage adjacent to capillary-sized telangiectasia (pre-existing dilated channels rather than proliferating vascular neoplasm) 3, .
Radiographic features
MRI
Pending.
DSA
Arterial stenosis and occlusion involving both large and small-sized intracranial and extracranial vessels.
Treatment and prognosis
Pending.
-<p><strong>Radiation-induced vasculopathy</strong> encompasses a complex and broad range of effects on the intra and extracranial vessels resulting from injury from radiation exposure.</p><h4>Clinical presentation</h4><p>Clinical symptoms are broad and depend on the underlying vasculopathy. Radiation-induced telangiectasia and microbleeds may be asymptomatic. However, patients may present with focal neurological deficits resulting from both <a href="/articles/intracerebral-haemorrhage">haemorrhagic</a> and <a href="/articles/ischaemic-stroke">ischaemic stroke</a>, lacunar lesions, vascular occlusive disease including <a href="/articles/moyamoya-syndrome-1">moyamoya syndrome</a>, vascular malformations, and radiation-induced necrosis.</p><h4>Pathology</h4><p>Biopsy and pathological analysis of radiation-induced telangiectasias has demonstrated deposition of perivascular hemosiderin and hemorrhage adjacent to capillary-sized telangiectasia (pre-existing dilated channels rather than proliferating vascular neoplasm) <sup>3</sup>, </p><h4>Radiographic features</h4><h5>MRI</h5><p><em>Pending. </em></p><h5>DSA</h5><p>Arterial stenosis and occlusion involving both large and small-sized intracranial and extracranial vessels.</p><h4>Treatment and prognosis</h4><p><em>Pending.</em></p>- +<p><strong>Radiation-induced vasculopathy</strong> encompasses a complex and broad range of effects on the intra and extracranial vessels resulting from injury from radiation exposure.</p><h4>Clinical presentation</h4><p>Clinical symptoms are broad and depend on the underlying vasculopathy. Radiation-induced telangiectasia and microbleeds may be asymptomatic. However, patients may present with focal neurological deficits resulting from both <a href="/articles/intracerebral-haemorrhage">haemorrhagic</a> and <a href="/articles/ischaemic-stroke">ischaemic stroke</a>, lacunar lesions, vascular occlusive disease including <a href="/articles/moyamoya-syndrome-1">moyamoya syndrome</a>, vascular malformations, and radiation-induced necrosis.</p><h4>Pathology</h4><p>Biopsy and pathological analysis of radiation-induced telangiectasias has demonstrated deposition of perivascular hemosiderin and hemorrhage adjacent to capillary-sized telangiectasia (pre-existing dilated channels rather than proliferating vascular neoplasm) <sup>3</sup>.</p><h4>Radiographic features</h4><h5>MRI</h5><p><em>Pending. </em></p><h5>DSA</h5><p>Arterial stenosis and occlusion involving both large and small-sized intracranial and extracranial vessels.</p><h4>Treatment and prognosis</h4><p><em>Pending.</em></p>