Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Niknejad M, Yap J, et al. Santorinicele. Reference article, Radiopaedia.org (Accessed on 30 Mar 2025) https://doi.org/10.53347/rID-8389
A santorinicele refers to a cystic dilatation of the end of the dorsal pancreatic duct (duct of Santorini) 1,2 and is believed to be analogous to a dilatation of the most distal common bile duct, which is commonly known as a choledochocele 3.
Diagnosis is based on morphology and relative dilatation as there is no specific measurement cut-off. Secretin-enhanced MRCP is more sensitive in detecting santoriniceles 6.
Because most santoriniceles have been reported in elderly patients, it has been assumed that a santorinicele is most probably an acquired rather than a congenital condition.
It usually occurs in association with pancreas divisum, but has been reported in isolation 5.
History and etymology
It was first described in 1994 by Eisen et al 4.
Which is true regarding pancreatic divisum?
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1. Manfredi R, Costamagna G, Brizi MG et-al. Pancreas divisum and "santorinicele": diagnosis with dynamic MR cholangiopancreatography with secretin stimulation. Radiology. 2000;217 (2): 403-8. Radiology (full text) - Pubmed citation
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2. Leyendecker JR, Elsayes KM, Gratz BI et-al. MR cholangiopancreatography: spectrum of pancreatic duct abnormalities. AJR Am J Roentgenol. 2002;179 (6): 1465-71. AJR Am J Roentgenol (full text) - Pubmed citation
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3. Nam KD, Joo KR, Jang JY, Kim NH, Lee SK, Dong SH, Kim HJ, Kim BH, Chang YW, Lee JI, Chang R. A case of santorinicele without pancreas divisum: diagnosis with multi-detector row computed tomography. (2006) Journal of Korean medical science. 21 (2): 358-60. doi:10.3346/jkms.2006.21.2.358 - Pubmed
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4. Eisen G, Schutz S, Metzler D, Baillie J, Cotton PB. Santorinicele: new evidence for obstruction in pancreas divisum. (1994) Gastrointestinal endoscopy. 40 (1): 73-6. Pubmed
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5. Byeon JS, Kim MH, Lee SK, Yang DH, Bae JS, Kim HJ, Lee SS, Seo DW, Min YI. Santorinicele without pancreas divisum. (2003) Gastrointestinal endoscopy. 58 (5): 800-3. Pubmed
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6. Boninsegna E, Manfredi R, Ventriglia A, Negrelli R, Pedrinolla B et al. Santorinicele: secretin-enhanced magnetic resonance cholangiopancreatography findings before and after minor papilla sphincterotomy. Eur Radiol. 2015;25(8):2437–44
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