Tc-99m DTPA

Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR).

Characteristics

• photon energy: 140 KeV
• physical half-life: 6 hours
• biological half-life: 2.5 hours
• normal distribution: kidneys (100%)
• pharmacokinetics
  • uptake by glomerular filtration (100%)
  • first pass filtration: 10-20%
• excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.
• target organ: bladder
• miscellaneous facts:
  • poor quality images with renal insufficiency

Uses, doses and timings

• renal study
• adult dose: 555 MBq (15 mCi) IV
• 60 sec flow study; then every 5 minutes for 25 minutes