Citation, DOI, disclosures and article data
Citation:
Rahman F, Smith D, Uhthoff phenomenon (multiple sclerosis). Reference article, Radiopaedia.org (Accessed on 25 Mar 2025) https://doi.org/10.53347/rID-90796
Uhthoff phenomenon refers to the temporary exacerbation (lasting less than 24 hours) of neurological symptoms secondary to increases in body temperature. This phenomenon is experienced by multiple sclerosis patients, though it also occurs in other demyelinating diseases 1.
History and etymology
The phenomenon was named after Wilhelm Uhthoff (1853-1927), a German ophthalmologist.
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1. Frohman TC, Davis SL, Beh S, Greenberg BM, Remington G, Frohman EM. Uhthoff's phenomena in MS--clinical features and pathophysiology. (2013) Nature reviews. Neurology. 9 (9): 535-40. doi:10.1038/nrneurol.2013.98 - Pubmed
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