SPECIMEN Specimen type: Needle core, left hemithyroid
Material received: 4 stained slides and 1 block
Left hemithyroid large mass. 18 G cook needle biopsy. ?Lymphoma. 2 cores.
MACROSCOPY (Transcribed from RFT report) Two needle cores. The largest measuring up to 20 mm.
REVIEW MICROSCOPY These are good sized core biopsies of lesional tissue with a few incomplete fibrous septa and a possible single epithelial element. The neoplastic infiltrate is composed of pleomorphic lymphocytes with centroblastic and large centrocytic morphology. No multinucleated giant cells or indolent lymphoma is noted. There is apoptosis and mitosis. No definite tumour necrosis noted. The phenotype of the neoplastic cells is as follows: PAX5, BCL2, BCL6, MUM1 - diffuse strong expression. CD3, CD5, CD21, AE1/AE3, cyclin-D1, CD10, CD23 - not expressed. AE1/AE3 - highlights a few possible residual epithelial elements. CD21 - emphasises two small possible follicular dendritic cell meshworks. Ki67 - brisk and around 85%.