Giant parietal foramina (GPF) (also foramina parietalia permagna, fenestrae parietals symmetricae) are symmetric bone defects caused by deficient ossification around the parietal notch. They are usually asymptomatic and can occur as an isolated finding or a part of a syndrome associated with gene defects. Occasionally, they can be associated with a vascular or cortical malformation and can present as epilepsy, headache, or other CNS complaints.