Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease, characterized by progressive degenerative changes of the upper and lower motor neurons (the condition is also called motor neuron disease) 1.
MRI findings include bilateral T2/FLAIR hyperintensity along the corticospinal tract extending from deep white matter into the centrum semiovale, internal capsule (mainly the posterior limb) and the anterior part of the brainstem. Corresponding diffusion restriction can be seen.