Following admission, the patient was shown to be HIV positive (new diagnosis, CD4+ 0.21 x 109 /L) and went on to have a biopsy.
Histology
Sections show multiple fragments of brain parenchyma showing a heavy perivascular mixed inflammatory cell infiltrate with many foamy macrophages. Foci of necrosis are identified. Bradyzoites and trophozoites of Toxoplasma gondii are identified in one area. No viral cytopathic changes are seen.
FINAL DIAGNOSIS: toxoplasmosis.
Toxoplasma gondii IgG Ab: Reactive
PCR on barin tissue: positive for toxoplasma DNA