Patient went on to have right posterior fossa craniotomy and resection of metastatic lesion. Intra-operatively, the metastatic lesion was noted to be multilobulated with a cystic component medially.

HISTOLOGY

MACROSCOPIC DESCRIPTION:

Multiple fragments of irregularly shaped light medium brown brain tissue 11g and 50 x 30 x 25mm in aggregate

MICROSCOPIC DESCRIPTION:

Sections demonstrate high grade metastatic carcinoma with a combination of solid and papillary and micropapillary architecture. The malignant cells have markedly pleomorphic nuclei with prominent nucleoli. The cells have a moderate amount of ampophilic cytoplasm with some hobnail forms seen. Areas of tumor necrosis are apparent. The tumor shows a sharp demarcation with adjacent cerebellar tissue

DIAGNOSIS:

Metastatic carcinoma - appearances consistent with origin from a high-grade ovarian serous carcinoma.