Ganglioglioma

Discussion:

The patient went on to have a temporal lobectomy. 

Histology

Mesial temporal tissue, partly infiltrated by astrocytic cells, with an admixture of large cells, with variable amounts of cytoplasm and one or more large nuclei. The features are consistent with an abnormal ganglion cell population. Some of these cells show positive staining for CD34. The nuclei of the astrocytic population are moderately pleomorphic. No mitotic activity is identified. There is no necrosis and microvascular proliferation is not seen. There is, however, some vessel wall thickening, with occasional vessels showing mild perivascular lymphocytic cuffing. The features are consistent with a ganglioglioma.


FINAL DIAGNOSIS: right medial temporal lobe and uncus - ganglioglioma (WHO grade 1)

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