Medulloblastomas are a common malignant CNS tumor in the pediatric group ^1,2,3,4, classified as WHO grade IV. The four major histopathological types consist of classic, desmoplastic-nodular, large cell/anaplastic, and extensive nodularity ^2,3,4.

The WHO currently genetic classification divides medulloblastomas into four molecular subgroups, which are wingless-WNT, sonic hedgehog-SHH, group 3, and group 4 ^1,3,4. This genetic classification is more predictive of clinical behavior and prognostic than tumor histology. Besides, it can be helpful in surgical planning, radiotherapy, and chemotherapy specific treatments ^1,3,4. MRI is an essential tool for predicting molecular medulloblastoma subgroups ^1,4.

This case illustrates histologically proven desmoplastic medulloblastoma, in the midline - vermis/fourth ventricle location.

Case courtesy

• Erick Cavalcante, MD - PGY-3, Radiology Resident, Department of Radiology
• Antonio Rodrigues de Aguiar Neto, MD - Radiologist, Department of Radiology
•  Hospital da Restauração – Recife, PE – Brazil