Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with pulmonary carcinoid tumor

Discussion:

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare lung condition characterized by the abnormal overgrowth of pulmonary neuroendocrine cells, of which this patient had histological proof. Usually, aspecific symptoms occur such as a chronic, non-productive cough, shortness of breath with exertion and wheezing.

It is considered to be a precancerous condition for pulmonary carcinoid tumors (well-differentiated neuroendocrine tumors). FDG PET CT can be helpful distinguishing between benign nodules and the ones showing malignant transformation. 

The presence of scattered multiple, rounded and ovoid pulmonary nodules and micronodules with mosaic pattern ground-glass opacities might raise the suspicion of DIPNECH.

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