Histology
Sections show brain tissue involved by a cellular and infiltrative tumour. The tumour cells have enlarged, angulated and hyperchromatic nuclei and abundant fibrillary cytoplasm. Mitotic figures are numerous and there are foci of glomeruloid microvascular proliferation and necrosis. Acute inflammation is not prominent. Appearances are of glioblastoma, WHO grade 4.
This is a historical case, and IDH mutation status was not routinely assessed at the time.