CT features of a unilocular expansile lucent lesion of the maxilla with scalloped, well-corticated borders suggestive of odontogenic keratocyst (OKC)

On imaging, the main differential diagnosis should include:

• ameloblastoma
  • tend to be multilocular, more expansile, with a "soap-bubble" or "honeycomb" appearance
  • tend to be more aggressive and cause more significant tooth resorption
  • long-standing OKC may mimic ameloblastoma
• dentigerous cyst
  • tend to attach at the cementoenamel junction of teeth
• radicular cyst 
  • centered at the apices of non-vital teeth
  • does not scallop, does not exhibit septation, and is often more expansile
• simple bone cyst
  • exhibit minimal expansion, and spare the lamina dura as well as the periodontal ligament spaces
  • OKC will tend to efface the lamina dura