Which of the following is least likely to be associated with this condition? a. positive antinuclear antigen b. positive rheumatoid factor c. increased erythrocyte sedimentation rate d. increased IgE
d. increased IgE.
What is the most likely diagnosis? a. idiopathic pulmonary fibrosis b Langerhans granulomatosis c. rheumatoid lung d. sarcoidosis
a. IPF
What are the differential diagnoses?
The differential diagnosis of UIP pattern interstitial lung disease includes: IPF, mixed connective tissue disease, asbestosis, chronic hypersensitivity pneumonitis, chronic drug toxicity, recurrent bout of aspiration and fibrosing NSIP.
Give a few examples of cytotoxic and non-cytotoxic medications whose toxicity may result in a UIP pattern interstitial lung disease?
1. cytotoxic drugs: bleomycin, busulfan, cyclophosphamide, methotrexate 2. non-cytotoxic drugs: amiodarone, gold salts, nitrofurantoin, oxygen
Bilateral symmetrical inter and intralobular septal thickening associated with architectural distortion traction bronchiectasis and honeycombing with more severe involvement toward the lung bases. Coronal MPR: typical distribution of fibrotic changes being peripheral and more toward the lung bases.
Mild to moderate oesophageal dilatation and small hiatus hernia. Mild enlargement of the mediastinal lymph nodes are seen.
The pulmonary artery is mildly dilated which could reflect pulmonary arterial hypertension.