Pathology report
Pathologic diagnosis:
- endoscopic ileal biopsy: chronic active ileitis. This could represent backwash ileitis
- endoscopic colonic biopsies: inflammatory bowel disease, probably ulcerative colitis, negative dysplasia
Gross description: several grey white soft tissue fragments.
Microscopic examination:
Ileal bites: show an intact surface epithelial covering with mild villous blunting and focal erosions, an increase in number of lymphocytes infiltrating the surface epithelium is seen. The lamina propria shows moderate mixed acute and chronic nonspecific inflammatory cellular infiltrate. The inflammatory response is composed of lymphohistiocytic infiltrate with several eosinophils. Several grouped neutrophils are seen. No granulomata. No lymphoid hyperplasia is seen. A few reactive follicles are seen. The muscularis mucosa is not hypertrophic. The infiltrate doesn't affect the submucosa. An increase in number of lymphocytes infiltrating the surface epithelium is seen.
The colonic fragments: show n intact surface epithelium with a disrupted glandular architecture. The inflammatory gradient is lost. The lamina propria shows a moderate chronic nonspecific inflammatory cellular infiltrate. Typical crypt abscesses are seen. No granulomata are detected. Basal plasmacytosis is seen with loss of inflammatory gradient. The muscularis mucosa is hypertrophic and is involved by the inflammatory infiltrate.