Identifying lymphoepithelial lesions of the parotid glands alludes to HIV and immune suppression in a highly prevalent local incidence. The usual differential diagnosis of Sjogren's syndrome and Mikulicz's syndrome still apply.

The presentation of confusion and seizure onset often portends a more sinister background. MRI studies and lumbar puncture, are often performed after HIV confirmation to confirm/exclude opportunistic intracranial sepsis/PML/HIV encephalopathy.