Primary CNS lymphoma

Discussion:

MRI brain done later on the same day was subpar due to extensive movement throughout the duration of the scan.

The mass was promptly biopsied.

Brain, right frontal region, biopsy:
The morphological and immunophenotypical features are consistent with diffuse large B-cell lymphoma of activated B-cell-like origin (ABC).
On immunostains, the lymphoma cells are positive for CD20, CD79a, BCL2, MUM1 ( more
than 50%), weakly positive for BCL6 ( 50-60%) and c-Myc( 40%) and are negative for CD10. The p53 is a weakly positive in a few scattered cells and the Ki67 proliferation antigen is positive in
70%-80% of the cells. The CD3 immunostain highlights a few scattered T-lymphocytes.

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