HISTOPATHOLOGY
DIAGNOSIS: 1 – 5) Multiple biopsies from a pineal tumour showing a central PINEAL GERMINOMA with surrounding reactive gliotic tissue. No other germ cell elements are seen. Supplementary immunohistochemistry to follow.
SUPPLEMENTARY IMMUNOHISTOCHEMISTRY: Immunohistochemical staining was performed on the best preserved tissue in Biopsy 4. No reactivity is seen with antibodies to beta HCG or alpha fetoprotein. The tumour cells show variable reactivity with antibody to PLAP confirming the diagnosis of pineal germinoma. The reactive lymphoid cells are predominantly T cells with some B cells.