Pituitary stalk interruption syndrome

Discussion:

Patient's lab investigations : 
Thyroid stimulating hormone (TSH) – 7.80 uIU/mL (0.4 to 4.2)
Free thyroid hormone (FT4) - 0.55ng/dL (0.89 to 1.76)
Prolactin -  22.7 ng/mL (3.0 to 14.7)
Testosterone -  1.4 ng/dL (2 to 800)

Pituitary stalk interruption syndrome is a very rare congenital syndrome, characterized by a classic triad of anterior pituitary hypoplasia or aplasia, ectopic or aplasic posterior pituitary and interrupted pituitary stalk.

The pathogenesis of this condition is still unknown.

Growth retardation is the most common presentation in older children and adults. Most patients lack sexual development.

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