This case illustrates a routine MRI brain follow-up study in a patient with a long-term history of multiple sclerosis. The aim is to identify disease progression. 

In our institution, this protocol is performed without post contrast sequences. New lesions can be spotted by comparison of the volumetric FLAIR sequences from the current and previous studies. 

Additionally, a MIP axial FLAIR is created as a fast track comparison of gross white matter lesion changes. The colorful sagittal volumetric acquisition represents the standard deviations of the volume of different cerebral regions compared to a control group in the same age range. It is a simple way to spot the diffuse and marked global brain atrophy in this patient.