Acute promyelocytic leukemia

Last revised by Yuranga Weerakkody on 5 Mar 2019

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Di Muzio B, Bell D, Acute promyelocytic leukemia. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-61061

DOI:

https://doi.org/10.53347/rID-61061

Permalink:

https://radiopaedia.org/articles/61061

rID:

61061

Article created:

15 Jun 2018, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

5 Mar 2019, Yuranga Weerakkody ◉

Disclosures:

At the time the article was last revised Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Revisions:

4 times, by 3 contributors - see full revision history and disclosures

Systems:

Haematology

Synonyms:

Acute promyelocytic leukemia (APML)
APML

Acute promyelocytic leukemia (APML) is a distinct subtype of acute myeloid leukemia.

Pathology

Genetics

It is defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha gene (RARα) on chromosome 17.