Acute promyelocytic leukemia
Acute promyelocytic leukemia (APML) is a distinct subtype of acute myeloid leukemia.
It is defined by a balanced translocation between chromosomes 15 and 17 resulting in fusion of the promyelocytic leukemia gene (PML) on chromosome 15 with the retinoic acid receptor alpha gene (RARα) on chromosome 17.
Treatment and prognosis
History and etymology
It was first described as a distinct entity in 1957.