Citation, DOI, disclosures and article data
Citation:
Gaillard F, Sharma R, Elfeky M, et al. Carney triad. Reference article, Radiopaedia.org (Accessed on 09 Dec 2024) https://doi.org/10.53347/rID-1055
Carney triad is a rare syndrome defined by the coexistence of three tumours:
In most cases, only two of the three tumours are present at the time of diagnosis, with the most common combination being GIST and pulmonary chondromas. Although not considered part of the triad, there is an increased incidence of adrenocortical adenoma, phaeochromocytoma, and oesophageal leiomyoma 6. It typically affects young people, with a female predilection 6. No underlying genetic mutation has been identified 6.
Terminology
It is not to be confused with the related Carney-Stratakis syndrome, or the unrelated Carney complex.
History and etymology
First described by J Aidan Carney, an American professor of pathology, and colleagues in 1977 5.
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1. Carney JA. Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence. Mayo Clin. Proc. 1999;74 (6): 543-52. doi:10.4065/74.6.543 - Pubmed citation
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2. Carney JA, Sheps SG, Go VL et-al. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N. Engl. J. Med. 1977;296 (26): 1517-8. doi:10.1056/NEJM197706302962609 - Pubmed citation
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3. Chew F, Banks K. American Journal of Roentgenology. 2006;187 (3_supplement): . doi:10.2214/AJR.06.0521
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4. Alrashdi I, Bano G, Maher ER, Hodgson SV. Carney triad versus Carney Stratakis syndrome: two cases which illustrate the difficulty in distinguishing between these conditions in individual patients. Familial cancer. 9 (3): 443-7. doi:10.1007/s10689-010-9323-z - Pubmed
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5. Carney JA. The Triad of Gastric Epithelioid Leiomyosarcoma, Functioning Extra-Adrenal Paraganglioma, and Pulmonary Chondroma. Cancer. 1979;43(1):374-82. doi:10.1002/1097-0142(197901)43:1<374::aid-cncr2820430152>3.0.co;2-t - Pubmed
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6. Stratakis C & Carney JA. The Triad of Paragangliomas, Gastric Stromal Tumours and Pulmonary Chondromas (Carney Triad), and the Dyad of Paragangliomas and Gastric Stromal Sarcomas (Carney-Stratakis Syndrome): Molecular Genetics and Clinical Implications. J Intern Med. 2009;266(1):43-52. doi:10.1111/j.1365-2796.2009.02110.x - Pubmed
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