CD34
Citation, DOI, disclosures and article data
Citation:
Feger J, Bell D, CD34. Reference article, Radiopaedia.org (Accessed on 23 Mar 2025) https://doi.org/10.53347/rID-87258
rID:
87258
Article created:
Disclosures:
At the time the article was created Joachim Feger had no recorded disclosures.
View Joachim Feger's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Joachim Feger had no recorded disclosures.
View Joachim Feger's current disclosures
Revisions:
4 times, by
2 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Haematopoietic progenitor cell antigen CD34
CD34 or haematopoietic progenitor cell antigen CD34 is an intercellular adhesion protein and cell surface glycoprotein and a frequently used marker of haematopoietic progenitor cells and endothelial cells. It is also expressed by many other non-haematopoietic cell types including multipotent mesenchymal stromal cells, interstitial dendritic cells and epithelial progenitors 1.
Usage
It serves as a target in immunohistochemistry where it can be used for the determination of vascularisation of tumours and disease processes and the differentiation of different tumours as:
- Kaposi sarcoma, dermatofibrosarcoma protuberans vs cutaneous fibrous histiocytoma
- solitary fibrous tumour vs desmoplastic mesothelioma
- confirmation of gastrointestinal stromal tumours
References
- 1. Sidney L, Branch M, Dunphy S, Dua H, Hopkinson A. Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors. Stem Cells. 2014;32(6):1380-9. doi:10.1002/stem.1661 - Pubmed
- 2. Lin C, Ning H, Lin G, Lue T. Is CD34 Truly a Negative Marker for Mesenchymal Stromal Cells? Cytotherapy. 2012;14(10):1159-63. doi:10.3109/14653249.2012.729817 - Pubmed
- 3. Parab T, DeRogatis M, Boaz A et al. Gastrointestinal Stromal Tumors: A Comprehensive Review. J Gastrointest Oncol. 2018;10(1):144-54. doi:10.21037/jgo.2018.08.20 - Pubmed
Incoming Links
Articles:
- Stromal tumour of uncertain malignant potential
- Infantile fibrosarcoma
- Atypical spindle cell/pleomorphic lipomatous tumour
- Acral fibromyxoma
- Cellular angiofibroma
- Solitary fibrous tumour
- NTRK-rearranged soft tissue neoplasm
- Angiomyofibroblastoma
- Deep fibrous histiocytoma
- Pleomorphic hyalinizing angiectatic tumour of soft parts
- Juxta-articular myxoma
- Epithelioid haemangioma of bone
- Anastomosing haemangioma
- Leiomyoma of soft tissue
- Aggressive angiomyxoma
- Epithelioid sarcoma
- Composite haemangioendothelioma
- Epithelioid haemangioma
- Retiform haemangioendothelioma
- Pseudomyogenic haemangioendothelioma
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blood
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histological stains
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- Masson's trichrome stain
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