Chronic granulomatous inflammatory process

Last revised by Henry Knipe on 16 Feb 2023

Chronic granulomatous inflammation is a disease process that mostly affects the soft tissues and is an inflammation where a compact collection of cells of the mononuclear phagocyte system, chiefly activated macrophages and cells derived from them are predominant 1.

There are two major categories of chronic granulomatous inflammation 2:

The disease is mostly considered to result from a response to pathogens and persistent irritants of either exogenous or endogenous origin 3. Often times, post surgical involvement also is a contributing factor.

Numerous mixed chronic inflammatory cells composed of lymphocytes, plasma cells, histiocytes and poorly formed granuloma on a fibroid background and multinucleated giant cells. sometimes, there is evidence of central necrosis.

Soft tissue edema with radio-lucent areas however. No gross skeletal bone involvement.

Diffuse soft tissue thickening (mostly peritendinous and/or purely subcutaneous in location) with mixed heterogenous echopattern and lobulations and sometimes interspersed with clear anechoic fluid areas. Color Doppler may be avascular or hypovascular. there may be presence of enlarged, reactive regional or distant lymph nodes.

If fluid is present, non-contrast T1W images will demonstrate central hypo-intensities while T2W images will demonstrate increased signal intensity regions in the background of thickened and lobulated mixed intensity soft tissue signal areas.

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.