Copper deficiency myeloneuropathy

Copper deficiency myeloneuropathy is rare, but increasingly recognised as a cause of neurological impairment, presenting similar to subacute combined degeneration of the cord secondary to B12 deficiency. 

Patients typically present with proprioceptive loss, due to dorsal column involvement, which manifests as a sensory ataxia 1

MRI is the modality of choice for assessing suspected cases. 

MRI

Spinal cord imaging demonstrates symmetric high T2 signal in the dorsal columns 1

In some patients findings suggestive of demyelination have been reported 1

Copper supplementation can arrest further neurological deterioration and even reverse symptoms and imaging findings 1

 

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rID: 45012
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