Citation, DOI, disclosures and article data
Citation:
Bell D, Deng F, Rasuli B, Frey syndrome. Reference article, Radiopaedia.org (Accessed on 19 Jan 2025) https://doi.org/10.53347/rID-67820
Frey syndrome (also known as Baillarger syndrome, Dupuy syndrome, and auriculotemporal syndrome) is a complication of parotid surgery. It clinically manifests as sweating and reddening in the region of the face supplied by the auriculotemporal nerve. The symptoms typically occur when tasting food, especially piquant flavors.
History and etymology
Frey syndrome was first described by the French neurologist and psychiatrist Jules Baillarger (1809-1890) in 1853 but his theory as to the cause was erroneous. Lucja Frey (1889-c.1942) 7, a Polish neurologist, working at the University of Warsaw, was the first to surmise in 1923 that it was a distinct pathological entity and correctly surmised that the intimate involvement of the auriculotemporal nerve was key to understanding the syndrome 2,4,6. The correct pathophysiology was elucidated by the French pediatric neurologist André-Thomas (1867-1963) 8 who formulated his aberrant regeneration theory, which was published in 1927 6. Curiously Dr. Thomas always insisted on having a hyphen between his first and last names 9!
Tragically Lucja Frey was murdered by the Nazis, and her exact date of death is not known, but documentary evidence points strongly towards 1942, as very likely the year of her death 7.
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1. Chulam TC, Noronha Francisco AL, Goncalves Filho J, Pinto Alves CA, Kowalski LP. Warthin's tumour of the parotid gland: our experience. (2013) Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale. 33 (6): 393-7. Pubmed
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2. Motz KM, Kim YJ. Auriculotemporal Syndrome (Frey Syndrome). (2016) Otolaryngologic clinics of North America. 49 (2): 501-9. doi:10.1016/j.otc.2015.10.010 - Pubmed
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3. Reynes P. [The Lucie Frey or auriculo-temporal syndrome]. (1983) Dental Cadmos. 51 (5): 95-100. Pubmed
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4. De Benedittis G. Auriculotemporal syndrome (Frey's syndrome) presenting as tic douloureux. Report of two cases. (1990) Journal of neurosurgery. 72 (6): 955-8. doi:10.3171/jns.1990.72.6.0955 - Pubmed
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5.Poirier J, Clarac F, Barbara JG, Broussolle E. Figures and Institutions of the neurological sciences in Paris from 1800 to 1950. Part IV: Psychiatry and psychology. (2012) Revue neurologique. 168 (5): 389-402. doi:10.1016/j.neurol.2012.02.007 - Pubmed
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6. Dulguerov P, Marchal F, Gysin C. Frey syndrome before Frey: the correct history. (1999) The Laryngoscope. 109 (9): 1471-3. doi:10.1097/00005537-199909000-00021 - Pubmed
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7. Moltrecht M, Michel O. The woman behind Frey's syndrome: the tragic life of Lucja Frey. (2004) The Laryngoscope. 114 (12): 2205-9. doi:10.1097/01.mlg.0000149459.98629.cf - Pubmed
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8. Duckett S. André-Thomas (1867-1963). (2000) Journal of neurology. 247 (3): 235-6. Pubmed
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9. Stephen Ashwal. The Founders of Child Neurology. (1990) ISBN: 9780930405267
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