Gadopentetate dimeglumine

Last revised by Dr Daniel MacManus on 13 Aug 2021

Gadopentetate dimeglumine (also known as MagnevistTM) is an extracellular intravenous contrast agent used in magnetic resonance imaging.

  • linear, ionic molecule 
  • 100% renally excreted
  • T1 relaxivity @ 1.5 T: 3.9-4.3
  • concentration: 0.5 mmol/mL
  • recommended dosage: 0.1 mmol/kg
Indications

As an extracellular contrast agent, gadopentetate dimeglumine can be useful in a wide range of MRI applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.

Contraindications

There is an association between the use of gadolinium-based contrast agents (GBCAs) in patients with kidney dysfunction and nephrogenic systemic fibrosis (NSF), a rare, but serious, condition. As a result, the use of three GBCAs; gadopentetate dimeglumine (Magnevist®), gadodiamide (Omniscan®), and gadoversetamide (OptiMARK®) are contraindicated in patients with AKI or with chronic, severe kidney disease 2.

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