Lumbosacral radiculoplexus neuropathy is a type of acute or subacute inflammatory neuropathy involving mainly the nerve roots of the lumbosacral nerve plexus 2. Diabetes mellitus is a major risk factor and in diabetics, this condition is called diabetic amyotrophy 3.
Present as an asymmetrical debilitating pain mainly involving the proximal thigh with associated motor weakness and atrophy of muscle 1.
There is acute or subacute inflammation of the nerve root and nerves causing a microvasculitis and ischemic nerve injury 2.
Treatment and prognosis
Current evidence suggests early treatment with immunosuppressive agents gives symptomatic relief and slows down disease progression 1.
- 1. Bhanushali, M.J. and Muley, S.A., 2008. Diabetic and non-diabetic lumbosacral radiculoplexus neuropathy. Neurology India, 56(4), p.420. doi:10.4103/0028-3886.44814
- 2. Dyck, P.J.B. and Thaisetthawatkul, P.,.Lumbosacral lexopathy. (2014) Continuum: Lifelong Learning in Neurology. 20 (5, Peripheral Nervous System Disorders): pp.1343-1358 doi:10.1212/01.CON.0000455877.60932.d3 - Pubmed
- 3. Peng Soon Ng, Peter J. Dyck, Ruple S. Laughlin, Prabin Thapa, Marcus V. Pinto, P. James B. Dyck. Lumbosacral radiculoplexus neuropathy. (2019) Neurology. 92 (11): e1188. doi:10.1212/WNL.0000000000007020 - Pubmed