Mammary myofibroblastoma

Last revised by Daniel J Bell on 27 Nov 2019

Mammary myofibroblastoma is a rare, benign, circumscribed mesenchymal breast tumor

It is the only breast tumor that occurs more commonly in males than females 2. It also has a tendency to occur more often in elderly males and postmenopausal women.

It arises from the stromal spindle cells of the breast 1. It stains positive for immunoreactive markers for desmin, smooth muscle, and actin.

  • circumscribed mass
  • no calcifications
  • greatest diameter no more than 1-4 cm

It usually has the appearance of a fibroadenoma:

  • circumscribed homogenous
  • slightly hypoechoic
  • circumscribed mass
  • internal septations
  • homogenous enhancement

Complete resection is recommended as it has a high rate of recurrence if not completely excised 3.


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