Mixed gonadal dysgenesis
Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
At the time the article was last revised Craig Hacking had the following disclosures:
- Philips Australia, Paid speaker at Philips Spectral CT events (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.View Craig Hacking's current disclosures
Depending on the chromosomal composition, patients may have testes and/or streak gonads.
- affected individuals are often 45XO/46XY
The absence of a second X chromosome may lead to the formation of a streak ovary in which the dysgenetic testis may invoke formation of hilar and medullary cords.
Neoplastic transformation may result from unprotected germ cells and abnormally high and prolonged gonadotropin stimulation with the risk exceeding 50% as the third decade is approached. These include: