Mixed gonadal dysgenesis

Mixed gonadal dysgenesis (MGD) is a type of gonadal dysgenesis characterised by gonadal asymmetry, and/or sex chromosomal mosaicism, as well as retained Müllerian ducts.

Depending on the chromosomal composition, patients may have testes and/or streak gonads.

Genetics
  • affected individuals are often 45XO/46XY
Associations

The absence of a second X chromosome may lead to the formation of a streak ovary in which the dysgenetic testis may invoke formation of hilar and medullary cords.

Neoplastic transformation may result from unprotected germ cells and abnormally high and prolonged gonadotropin stimulation with the risk exceeding 50% as the third decade is approached. These include: 

Share article

Article Information

rID: 15547
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Mixed gonadal dysgenesis (MGD)
  • MGD

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.