Morvan syndrome
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Morvan syndrome, also known as Morvan fibrillary chorea, is a rare syndrome thought to be either paraneoplastic or autoimmune in origin.
Clinical presentation
It is characterised by:
- neuromyotonia
- pain
- hyperhydrosis
- weight loss
- severe insomnia
- hallucinations
Pathology
Voltage gated potassium channel (VGKC) antibodies, in particular anti-CASPR2, are frequently present in this syndrome5.
History and etymology
The condition is named after the French physician, Augustin Marie Morvan (1819-1897) who first described it in 1890 3,4.
References changed:
- 5. van Sonderen A, Ariño H, Petit-Pedrol M et al. The Clinical Spectrum of Caspr2 Antibody-Associated Disease. Neurology. 2016;87(5):521-8. <a href="https://doi.org/10.1212/WNL.0000000000002917">doi:10.1212/WNL.0000000000002917</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/27371488">Pubmed</a>
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