Disclosures
- updated 18 Aug 2024:
Nothing to disclose
Updates to Article Attributes
Morvan syndrome, also known as Morvan fibrillary chorea, is a rare syndrome, similar to Isaacs syndrome, thought to be either paraneoplastic orand/or autoimmune in origin.
Clinical presentation
It is characterised by:
neuromyotonia
pain
hyperhydrosis
weight loss
severe insomnia
hallucinations
Pathology
Voltage gated potassium channel (VGKC) antibodies, in particular anti-CASPR2, are frequently present in this syndrome 5.
History and etymology
The condition is named after the French physician, Augustin Marie Morvan(1819-1897) who first described it in 1890 3,4.
Differential diagnosis
-<p><strong>Morvan syndrome</strong>, also known as <strong>Morvan fibrillary chorea</strong>, is a rare syndrome thought to be either paraneoplastic or autoimmune in origin.</p><h4>Clinical presentation</h4><p>It is characterised by:</p><ul>-<li>neuromyotonia</li>-<li>pain</li>-<li>hyperhydrosis</li>-<li>weight loss</li>-<li>severe insomnia</li>-<li>hallucinations</li>-</ul><h4>Pathology</h4><p>Voltage gated potassium channel (VGKC) antibodies, in particular anti-CASPR2, are frequently present in this syndrome <sup>5</sup>.</p><h4>History and etymology</h4><p>The condition is named after the French physician, <strong>Augustin Marie Morvan</strong> (1819-1897) who first described it in 1890 <sup>3,4</sup>.</p>- +<p><strong>Morvan syndrome</strong>, also known as <strong>Morvan fibrillary chorea</strong>, is a rare syndrome, similar to <a href="/articles/isaacs-syndrome" title="Isaacs syndrome">Isaacs syndrome</a>, thought to be either paraneoplastic and/or autoimmune in origin.</p><h4>Clinical presentation</h4><p>It is characterised by:</p><ul>
- +<li><p>neuromyotonia</p></li>
- +<li><p>pain</p></li>
- +<li><p>hyperhydrosis</p></li>
- +<li><p>weight loss</p></li>
- +<li><p>severe insomnia</p></li>
- +<li><p>hallucinations</p></li>
- +</ul><h4>Pathology</h4><p>Voltage gated potassium channel (VGKC) antibodies, in particular anti-CASPR2, are frequently present in this syndrome <sup>5</sup>.</p><h4>History and etymology</h4><p>The condition is named after the French physician, <strong>Augustin Marie Morvan</strong> (1819-1897) who first described it in 1890 <sup>3,4</sup>.</p><h4>Differential diagnosis</h4><ul>
- +<li><p><a href="/articles/stiff-person-syndrome-1" title="Stiff person syndrome">stiff person syndrome</a></p></li>
- +<li><p><a href="/articles/progressive-encephalomyelitis-with-rigidity-and-myoclonus" title="Progressive encephalomyelitis with rigidity and myoclonus">progressive encephalomyelitis with rigidity and myoclonus</a></p></li>
- +</ul>
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