N-acetylcysteine (NAC) if often used as a prophylaxis against contrast-induced nephropathy. Protocols for administration vary widely from institution to institution and the true efficacy is still controversial.
A typical protocol is [1-2]:
- 600 mg acetylcysteine twice daily on the day of the examination
- +/- 600 mg twice daily the day before the examination
- 1. “Prophylaxis of Contrast Material–induced Nephropathy in Patients in Intensive Care: Acetylcysteine, Theophylline, or Both? A Randomized Study1,” June 1, 2006. [Link].
- 2. Poletti Pierre-Alexandre, Patrick Saudan, Alexandra Platon et al. “IV N-Acetylcysteine and Emergency CT: Use of Serum Creatinine and Cystatin C as Markers of Radiocontrast Nephrotoxicity.” Am. J. Roentgenol. 189, no. 3 (September 1, 2007): 687-692. doi:10.2214/AJR.07.2356.