Weerakkody Y, Sharma R, Gaillard F, New-onset refractory status epilepticus. Reference article, Radiopaedia.org (Accessed on 23 Mar 2025) https://doi.org/10.53347/rID-60965
de novo cryptogenic refractory multifocal febrile status epilepticus
New-onset refractory status epilepticus (NORSE) is defined as refractory status epilepticus occurring in a previously healthy patient with no known history of epilepsy, who has no identifiable structural, toxic or metabolic cause for their refractory status epilepticus found on initial investigation.
Treatment is with aggressive initiation and uptitration of antiseizure medications (including anaesthesia and ketogenic diet) and early consideration of immunomodulatory treatments (e.g. corticosteroids, intravenous immunoglobulin, rituximab, tocilizumab, anakinra, etc.) 7.
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