Oesophageal leiomyoma

Last revised by Mostafa Elfeky on 23 May 2023

Oesophageal leiomyoma is a benign smooth muscle neoplasm of the oesophagus. It is the most common benign tumour of the oesophagus.

It is most frequently presents in young and middle age groups (20-50 years). The overall incidence is around 8-43 per 10,000 autopsy series 4.

The clinical presentation would often depend on the size of a tumour:

  • small tumours (<5 cm): usually no symptoms
  • large tumours: may cause dysphagia, regurgitation, oesophageal obstruction, chest pain, cough, or bleeding (rare)

Like other leiomyomas, they comprise smooth muscle overgrowth.

They typically involve the mid-to-distal oesophagus 4.

On barium swallow, may be seen as a discrete ovoid mass that is well outlined by barium. Its borders form slightly obtuse angles with the oesophageal wall.

Findings include:

  • ovoid intramural solitary mass with a smooth surface
  • the presence of calcifications is almost pathognomonic 
  • narrowing of the oesophageal lumen
  • may displace the oesophagus
  • moderate diffuse contrast-enhancement
  • no signs of invasion of adjacent tissue

The overall prognosis of these benign tumours is excellent. If a tumour is small (<5 cm) and asymptomatic treatment is not necessary. Otherwise, surgical enucleation is recommended 1,5.

Imaging differential considerations include:

Cases and figures

  • Case 1
  • Case 2
  • Case 3: on barium
  • Case 3: on CT
  • Case 4
  • Case 5

Imaging differential diagnosis

  • Oesophageal carcinoma
  • Gastroinstestinal stromal tumour (GIST)
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