Paraquat-induced lung disease
Updates to Article Attributes
Paraquat included-induced lung disease is a potential consequence of accidental or malintended consequence of ingestion of the non selective herbicical-selective herbicidal agent Paraquat -paraquat (a.k.a. N,N′-dimethyl-4,4′-bipyridinium dichloride).
Radiographic features
GenaralGeneral features
Changes tend to progressA temporal progression from ground glass opacities, through air space consolidation, and finally to fibrosis.
CT - HRCT Chest
Changes usually being begin with ground-glass attenuationopacities, which can then to leadslead to consolidation with bronchiectasis or irregular lines 2.
Some patients may also develop a pneumomediastinum +/- pneumothoraxpneumothorax 4.
Focal honeycombing can occur after after a few weeks. In patients to tend towho survive longer, later imaging(i.e. months later) may show aras areas of localised fibrosis containing small cysts 4.
PrognosisTreatment and prognosis
Once there is lung disease, the condition is thought to carry a very poor prognosis, with most patientsthe majority inexorably progressing to end-stage respiratory failure1-3.
See also
-<p><strong>Paraquat included lung disease</strong> is a potential consequence of accidental or malintended ingestion of the non selective herbicical agent Paraquat - N,N′-dimethyl-4,4′-bipyridinium dichloride. </p><h4>Radiographic features</h4><h5>Genaral features</h5><p>Changes tend to progress from air space consolidation to fibrosis.</p><h5>CT - HRCT Chest</h5><p>Changes usually being with ground-glass attenuation, which can then to leads to consolidation with bronchiectasis or irregular lines <sup>2</sup>.</p><p>Some patients may also develop a pneumomediastinum + / - pneumothorax <sup>4</sup>. </p><p>Focal honeycombing can occur after a few weeks. In patients to tend to survive longer, later imaging (i.e months later) may show aras of localised fibrosis containing small cysts <sup>4</sup>.</p><h4>Prognosis</h4><p>Once there is lung disease, the condition is thought to carry a very poor prognosis, with most patients progressing to respiratory failure <sup>1-3</sup>.</p><h4>See also</h4><ul><li><a title="Drug induced lung disease" href="/articles/drug-induced-lung-disease">drug induced lung disease</a></li></ul>- +<p><strong>Paraquat-induced lung disease</strong> is a potential consequence of ingestion of the non-selective herbicidal agent paraquat (a.k.a. N,N′-dimethyl-4,4′-bipyridinium dichloride).</p><h4>Radiographic features</h4><h5>General features</h5><p>A temporal progression from <a title="Ground glass opacities (GGO)" href="/articles/ground-glass-opacification-1">ground glass opacities</a>, through <a title="Air space consolidation" href="/articles/air-space-opacification-1">air space consolidation</a>, and finally to <a title="Fibrosis of lung" href="/articles/pulmonary-fibrosis">fibrosis</a>.</p><h5>CT - HRCT Chest</h5><p>Changes usually begin with ground-glass opacities, which can then lead to consolidation with <a title="Bronchiectasis" href="/articles/bronchiectasis">bronchiectasis</a> or irregular lines <sup>2</sup>.</p><p>Some patients may also develop a <a title="Pneumomediastinum" href="/articles/pneumomediastinum">pneumomediastinum</a> +/- <a title="Pneumothorax" href="/articles/pneumothorax">pneumothorax</a> <sup>4</sup>.</p><p>Focal honeycombing can occur after a few weeks. In patients who survive longer, later imaging (i.e. months) may show areas of localised fibrosis containing small cysts <sup>4</sup>.</p><h4>Treatment and prognosis</h4><p>Once there is lung disease, the condition is thought to carry a very poor prognosis, with the majority inexorably progressing to <a title="Respiratory failure" href="/articles/respiratory-failure">end-stage respiratory failure</a> <sup>1-3</sup>.</p><h4>See also</h4><ul><li><a href="/articles/drug-induced-lung-disease-1">drug-induced lung disease</a></li></ul>