Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Kumar K, Gaillard F, Parathyroid lipoadenoma. Reference article, Radiopaedia.org (Accessed on 16 Mar 2025) https://doi.org/10.53347/rID-170339
Parathyroid lipoadenomas are extremely rare tumors that are often considered a variant of a parathyroid adenoma.
Epidemiology
There may be slight female predilection based on limited studies 2.
Clinical presentation
Patients may present with primary hyperparathyroidism.
Pathology
Histologically, almost all parathyroid lipoadenomas consist of > 50% mature adipose tissue.
Radiographic features
Ultrasound
Parathyroid lipoadenomas may be seen as juxtathyroid lesions. They may appear more echogenic/hyperechoic due to their fat content 4.
History and etymology
It is believed that parathyroid lipoadenomas were first described by Ober and Kaiser in 1958 7.
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1. Juhlin C, Falhammar H, Zedenius J, Nilsson I, Höög A. Lipoadenoma of the Parathyroid Gland: Characterization of an Institutional Series Spanning 28 Years. Endocr Pathol. 2020;31(2):156-65. doi:10.1007/s12022-020-09616-3 - Pubmed
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2. Chow L, Erickson L, Abu-Lebdeh H, Wermers R. Parathyroid Lipoadenomas: A Rare Cause of Primary Hyperparathyroidism. Endocr Pract. 2006;12(2):131-6. doi:10.4158/EP.12.2.131 - Pubmed
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3. Özden S, Güreşci S, Saylam B, Dağlar G. A Rare Cause of Primary Hyperparathyroidism: Parathyroid Lipoadenoma. Auris Nasus Larynx. 2018;45(6):1245-8. doi:10.1016/j.anl.2018.05.001 - Pubmed
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4. Cammarata F, Yakushkina A, Pennacchi L et al. Atypical Primary Hyperparathyroidism Due to Parathyroid Lipoadenoma: A Case Report. Journal of Surgical Case Reports. 2021;2021(7):rjab308. doi:10.1093/jscr/rjab308 - Pubmed
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5. Bleiweiss I, Harpaz N, Strauchen J, Wagner R, Biller H. Functioning Lipoadenoma of the Parathyroid: Case Report and Literature Review. Mt Sinai J Med. 1989;56(2):114-7. - Pubmed
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6. Aggarwal A, Wadhwa R, Aggarwal V. Parathyroid Lipoadenoma: A Rare Entity. Indian J Endocrinol Metab. 2018;22(1):174-6. doi:10.4103/ijem.IJEM_273_17 - Pubmed
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7. Turner W, Baergen R, Pellitteri P, Orloff L. Parathyroid Lipoadenoma: Case Report and Review of the Literature. Otolaryngol--Head Neck Surg. 1996;114(2):313-6. doi:10.1016/s0194-59989670193-6 - Pubmed
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