Werner syndrome

Werner syndrome is a progeroid rare autosomal recessive condition attributed to chromosome 8. It should not to be confused with similarly sounding Wermer syndrome.

Werner syndrome is characterised by

  • premature senescence
  • cataracts
  • short stature
  • scleroderma-like skin changes such as hyperkeratotic skin, soft tissue calcification
  • endocrine abnormalities such diabetes mellitus and hypogonadism
Associations

The syndrome also carries an increased risk of malignancy (particularly sarcoma formation 2). 

A general manifestation is valvular, soft tissue and/or arterial calcification from premature atherosclerosis. Musculoskeletal manifestations includes:

First described by Otto Werner, German scientist, in 1904.

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Article Information

rID: 8003
Section: Syndromes
Synonyms or Alternate Spellings:
  • Werner's syndrome

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