Werner syndrome is characterised by
- premature senescence
- short stature
- scleroderma-like skin changes such as hyperkeratotic skin, soft tissue calcification
- endocrine abnormalities such diabetes mellitus and hypogonadism
The syndrome also carries an increased risk of malignancy (particularly sarcoma formation 2).
A general manifestation is valvular, soft tissue and/or arterial calcification from premature atherosclerosis. Musculoskeletal manifestations includes:
- osteoporosis: either generalised or localised to the peripheries
- osteosclerosis: phalangeal predominant 1
First described by Otto Werner, German scientist, in 1904.
- 1. Goto M, Kindynis P, Resnick D et-al. Osteosclerosis of the phalanges in Werner syndrome. Radiology. 1989;172 (3): 841-3. Radiology (abstract) - Pubmed citation
- 2. Walton NP, Brammar TJ, Coleman NP. The musculoskeletal manifestations of Werner's syndrome. J Bone Joint Surg Br. 2000;82 (6): 885-8. J Bone Joint Surg Br (link) - Pubmed citation