Alzheimer disease

Case contributed by A.Prof Frank Gaillard

Presentation

Progressive impairment of recent/short-term memory with relative preservation of remote and autobiographical memory.

Patient Data

Age: 70 years
Gender: Female
Modality: MRI

The sulci and ventricles are mildly more prominent than expected for age. The mesiotemporal structures, including the temporal horns of the lateral ventricles and the collateral sulci, are slightly more prominent, with bilateral hippocampi and entorhinal cortices of reduced volume.

Multiple FLAIR hyperintense lesions in the supratentorial white matter, confluent in the periventricular regions, are in keeping with mild to moderate small vessel ischaemia.

No diffusion restriction or suspicious susceptibility.

Case Discussion

Findings are typical of the clinically suspected mild Alzheimer disease. As brain biopsy is rarely carried out imaging plays an important role in confirming the clinical impression of dementia. This is increasingly so as some therapies are emerging. 

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Case Information

rID: 22196
Case created: 19th Mar 2013
Last edited: 16th Sep 2015
Inclusion in quiz mode: Included

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