Chondrosarcoma - sphenoid wing

Case contributed by A.Prof Frank Gaillard

Case Discussion

CT and MRI images demonstrate an extraaxial lesion arising from just lateral to the clivus and cavernous sinus. It is of mixed density on CT with regions of calcifications.

On MRI the lesion is heterogeneous in signal with the more medial component demonstrated high T2 signal and variegated contrast enhancement, without restricted diffusion.

Features are consistent with a chondrosarcoma (histologically proven). The off-midline location and ring-like calcification makes a chordoma much less likely.

Final Diagnosis:

Sphenoid wing lesion, excision: Chondrosarcoma, low-grade (2/3).

Microscopic Description: 

Sections show a moderately cellular cartilage-forming neoplasm with large areas of tumor necrosis. The tumor cells are round to polygonal with hyperchromatic nuclei and are embedded in hyaline chondromatous matrix. There are foci, however, in which the tumor cells are stellate to spindle in shape, have slightly vacuolated cytoplasm and are embedded in myxoid stroma. The tumor cells are diffusely and strongly positive for S-100 protein and negative for EMA and cytokeratin.

PlayAdd to Share

Case information

rID: 5421
Case created: 20th Jan 2009
Last edited: 7th Dec 2015
Inclusion in quiz mode: Included

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.