Glioblastoma IDH wild-type

Case contributed by Bahman Rasuli
Diagnosis certain

Presentation

Seizures and right-sided hemiplegia.

Patient Data

Age: 50 years
Gender: Male
mri
This study is a stack
Axial
T2
This study is a stack
Axial
T1
This study is a stack
Axial
FLAIR
This study is a stack
Coronal
T2
This study is a stack
Sagittal
T2
This study is a stack
Axial
T1 C+
This study is a stack
Coronal
T1 C+
This study is a stack
Sagittal
T1 C+
This study is a stack
Axial
DWI
This study is a stack
Axial
ADC
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Info

MRI demonstrates a large heterogenous signal intra-axial mass in the left parietal-temporal lobes. It exerts a significant mass effect with a midline shift and compression of the left lateral ventricle occipital horn and is surrounded by vasogenic edema.

The lesion shows patches of diffusion restriction and heterogenous post-contrast enhancement.

Case Discussion

MRI features are most consistent with a high-grade (WHO grade IV) primary glial tumor. Biopsy confirmed this to be a glioblastoma multiform, IDH wild type, WHO grade IV.

IHC results:

Oligo2: positive

GFAP: positive

IDH1: negative

EMA: negative

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