IMPORTANT: We currently have a number of bugs related to image cropping and are actively trying to resolve them. In the meantime, we have disabled cropping. Apologies for any inconvenience. Stay informed: radiopaedia.org/chat

Kallmann syndrome

Case contributed by Frank Gaillard
Diagnosis almost certain

Presentation

History withheld.

Patient Data

Age: 15 years
Gender: Female

Note: This case has been tagged as "legacy" as it no longer meets image preparation and/or other case publication guidelines.

MRI brain (single image)

mri

Single coronal T2 image through the frontal lobes demonstrates abnormal anatomy with absence of the olfactory bulbs and olfactory sulcus. The gyrus rectus and medial orbital gyrus form a single gyrus. 

Annotated images

Annotated image

It is easiest to appreciate the anatomical anomalies present in Kallman syndrome by comparing it to a normal patient. The normal anatomy of the region consists of the olfactory bulbs (blue arrows) located in the olfactory grooves of the anterior cranial fossa. The inferior surface of the frontal lobes usually consists of gyrus rectus (aka straight gyrus) (R) separated from the medial orbital gyrus (M) by the olfactory sulcus (yellow arrow). These are absent in Kallman syndrome. 

Case Discussion

Kallmann syndrome is rare, but has characteristic imaging findings which should be sought in patients with delayed onset of puberty/hypogonadism. 

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.