Pineocytoma with astrocytic differentiation

Case contributed by A.Prof Frank Gaillard

Presentation

Increasing headaches

Patient Data

Age: Adult
Modality: MRI

A large enhancing mass is present in the pineal region compressing the tectum and resulting in obstructive hydrocephalus. 

The patient went on to have surgery and resection of the mass. 

Histology

Sections show a tumour comprised of cells with small rounded nuclei with a moderate degree of pleomorphism. Some hyperchromatic nuclei are present, some of these with eosinophilic cytoplasmic inclusions. Cells show minimal cytoplasm but show elongated cell processes. In many areas the tumour shows anuclear zones. Mitoses are rare (there is only one seen in all of the sections). There is no endothelial proliferation and there is no necrosis. Immunohistochemistry shows that the tumour is strongly positive for synaptophysin and focally positive for neuron-specific enolase. Many of the tumour cells are positive for glial fibrillary acidic protein (GFAP).

Case Discussion

Path proven pineocytoma.

PlayAdd to Share

Case Information

rID: 4068
Case created: 16th Jul 2008
Last edited: 31st Dec 2016
Inclusion in quiz mode: Included

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.